Rapid large-scale screening of blood proteins by use of cellulose acetate electrophoresis on a solid support.

We describe a new principle of cellulose acetate electrophoresis (solid-support electrophoresis), in which cellulose acetate membranes are given a solid support, instead of being suspended as heretofore. The new technique is particularly well suited for screening procedures, because many samples can be processed economically on a single run. Also described for the first time, in conjunction with solid-support electrophoresis, is a method of (a) simultaneously using continuous and discontinuous buffer systems with specially (series) oriented membranes, or (b) a single-sample application for fractionating different constituents simultaneously (proteins, lipoproteins, isoenzymes, etc.).